This study aimed to determine the used of problem-based learning and inquiry learning model with Macromedia Flash on students’ learning outcomes and learning activities. The population in this study was 8 classes of XI Natural Science students of MAN 1 Medan. The sample was 20 students selected based on the homogeneity of the pretest scores and questionnaires. Experimental class that I received the problem-based learning and inquiry learning model with Macromedia Flash, while experimental class II received the problem-based learning and inquiry learning model. The data analysis showed a mean score of 84.25 and 75.25 in experimental class I and II respectively. The results of the statistical test using the right-side t-test for learning outcomes obtained t-count = 4.15 and t-table = 1.686 for α = 0.05. The hypothesis testing for learning activities obtained t-count = 3.15 with t-table = 1.686 for α = 0.05. If the t-count is higher than the t-table, the hypothesis of students’ learning outcomes and learning activities is accepted and Ho is rejected. Learning outcomes and learning activities using the problem-based learning and inquiry learning model with Macromedia Flash are higher than those using the problem-based learning and inquiry learning model.